Primary Hyperparathyroidism: Epidemiological, Clinical, and Therapeutic Features in a Tertiary Hospital Cohort
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Abstract
Primary hyperparathyroidism (PHPT) is an endocrine disorder characterized by inappropriate secretion of parathyroid hormone (PTH), leading to hypercalcemia. Although biochemical screening has increased the diagnosis of asymptomatic forms in developed countries, PHPT continues to be diagnosed at symptomatic stages in other regions. Data from North Africa are limited.
The aim of this study was to describe the epidemiological, clinical, paraclinical, and therapeutic characteristics of patients with PHPT treated in two referral hospitals in Rabat, Morocco.
Materials and methods: A descriptive study was conducted including adult patients with a confirmed diagnosis of PHPT managed between January 2015 and December 2022 at Ibn Sina University Hospital and Mohamed V Military Hospital.
Results: Eighty-three patients were included, with a mean age of 53.27 ± 16.86 years and a marked female predominance (90.4%). PHPT was asymptomatic in 39.7% of cases. Osteoarticular manifestations were the most frequent (56.6%). Cervical ultrasound and sestamibi scintigraphy showed sensitivities of 89.1% and 92%, respectively. Surgical treatment was performed in 95.18% of patients.
Conclusion: PHPT was frequently diagnosed at symptomatic stages, with a high burden of skeletal involvement. Early detection through systematic serum calcium measurement and timely surgical management are essential to prevent complications and improve long-term outcomes.
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